A study has revealed for the first time that nutritional mineral intake can bring about the formation of calciprotein monomers (CPM) and calciprotein particles (CPP) in blood as a normal physiological response to feeding. Similar effects were seen in individuals with normal and impaired kidney function. However, the postprandial excursion of serum CPM was more significantly seen in chronic kidney disease (CKD) patients. The study also reported an early and transient postprandial effect on T50, which was present irrespective of the kidney function status and along with a co-existing rise in serum fetuin-A. 

These findings have given strength to the earlier hypothesis that CPM/CPP formation assists in buffering postprandial mineral loads, acting as a temporary store of bulk calcium phosphates eventually intended for utilization or storage, or elimination. 

Reference

Tiong MK, Cai MMX, Toussaint ND, et al. Effect of nutritional calcium and phosphate loading on calciprotein particle kinetics in adults with normal and impaired kidney function. Sci Rep. 2022;12(1):7358.